Branched Chain Aminotransferase 1, Cytosolic (BCAT1) Antibody

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.

Target	Branched Chain Aminotransferase 1, Cytosolic (BCAT1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 81-107 amino acids from the Central region of human BCAT1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P54687 (UniProt, ExPASy)
UniProt Secondary AC	B3KY27, B7Z2M5, B7Z5L0, F5H5E4, Q68DQ7, Q96MY9
UniProt Entry Name	BCAT1_HUMAN
NCBI Accession	NP_001171562.1 NP_001171563.1 NP_001171564.1 NP_001171565.1 NP_005495.2
KEGG	hsa:586
String	9606.ENSP00000443459
Molecular Weight	Calculated MW: 43 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Sheep BCAT1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Branched Chain Aminotransferase 1, Cytosolic (BCAT1)

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