Bcl-w (BH3 Domain Specific) Antibody

Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero or homodimers and act as anti and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.

Target	Bcl-w (BH3 Domain Specific)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 24-59 amino acids from human Bcl.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q92843 (UniProt, ExPASy)
UniProt Secondary AC	A8K0F4, Q2M3U0, Q5U0H4
NCBI Accession	NP_001186768.1 NP_004041.1
Molecular Weight	Calculated MW: 20.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow BCL2L2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Bcl-w (BH3 Domain Specific)

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