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Bcl2 Like Protein 13 (BCL2L13) Antibody
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Catalogue No: abx001026
Price:
US$348.00
(Size: 60 µl)
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BCL2L13 Antibody is a Rabbit Polyclonal antibody against BCL2L13. Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.
Research Articles on Bcl2 Like Protein 13 (BCL2L13)
| Target | Bcl2 Like Protein 13 (BCL2L13) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human BCL2L13 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9BXK5 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KPE7, Q96B37, Q96IB7, Q9BY01, Q9HC05, Q9UFE0, Q9UKN3 |
| UniProt Entry Name | B2L13_HUMAN |
| Gene Symbol | BCL2L13 |
| GeneID | 23786 |
| NCBI Accession | NP_056182.2 |
| String | 9606.ENSP00000480836 |
| Molecular Weight | Calculated MW: 22 kDa/34 kDa/52 kDa Observed MW: 48 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |