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Bestrophin-1 (BEST1) Antibody
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Catalogue No: abx004386
Price:
US$217.50
(Size: 20 µl)
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BEST1 Antibody is a Rabbit Polyclonal antibody against BEST1. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Research Articles on Bestrophin-1 (BEST1)
| Target | Bestrophin-1 (BEST1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 376-585 of human BEST1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O76090 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K0W6, B7Z3J8, B7Z736, O75904, Q53YQ9, Q8IUR9, Q8IZ80 |
| UniProt Entry Name | BEST1_HUMAN |
| Gene Symbol | BEST1 |
| GeneID | 7439 |
| NCBI Accession | NP_004174.1 |
| KEGG | hsa:7439 |
| String | 9606.ENSP00000399709 |
| Molecular Weight | Calculated MW: 68 kDa Observed MW: 68 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |