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Beta-Secretase 1 (BACE1) Antibody
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Catalogue No: abx148521
Price:
US$406.00
(Size: 100 µg)
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Beta-Secretase 1 (BACE1) Antibody is a Rabbit Polyclonal antibody for the detection of BACE1. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Research Articles on Beta-Secretase 1 (BACE1)
| Target | Beta-Secretase 1 (BACE1) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | beta-site APP-cleaving enzyme 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P56817 (UniProt, ExPASy) |
| UniProt Secondary AC | A0M8W7, B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1 |
| UniProt Entry Name | BACE1_HUMAN |
| Gene Symbol | BACE1 |
| GeneID | 23621 |
| OMIM | 604252 |
| HGNC | 933 |
| KEGG | hsa:23621 |
| Ensembl | ENSG00000186318 |
| String | 9606.ENSP00000318585 |
| Molecular Weight | Observed MW: 50-55 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |