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Tyrosine-Protein Kinase BLK (BLK) Antibody
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Catalogue No: abx015724
Price:
US$427.75
(Size: 100 µl)
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BLK (B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage.B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7.Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
Research Articles on Tyrosine-Protein Kinase BLK (BLK)
| Target | Tyrosine-Protein Kinase BLK (BLK) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of BLK expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P51451 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16291, Q96IN1 |
| UniProt Entry Name | BLK_HUMAN |
| Gene Symbol | BLK |
| GeneID | 640 |
| OMIM | 191305 |
| HGNC | 1057 |
| KEGG | hsa:640 |
| Ensembl | ENSG00000136573 |
| String | 9606.ENSP00000259089 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |