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Polycomb Complex Protein BMI-1 (BMI1) Antibody
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Catalogue No: abx031610
Price:
US$326.25
(Size: 80 µl)
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BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
Research Articles on Polycomb Complex Protein BMI-1 (BMI1)
| Target | Polycomb Complex Protein BMI-1 (BMI1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P35226 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16030, Q5T8Z3, Q96F37 |
| UniProt Entry Name | BMI1_HUMAN |
| NCBI Accession | NP_001190991.1 NP_005171.4 |
| KEGG | hsa:100532731 hsa:648 |
| String | 9606.ENSP00000473391 |
| Molecular Weight | Calculated MW: 36.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Cow and Chicken BMI1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |