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Bone Morphogenetic Protein Receptor 2 (BMPR2) Antibody
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Catalogue No: abx004334
Price:
US$217.50
(Size: 20 µl)
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BMPR2 Antibody is a Rabbit Polyclonal antibody against BMPR2. This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Research Articles on Bone Morphogenetic Protein Receptor 2 (BMPR2)
| Target | Bone Morphogenetic Protein Receptor 2 (BMPR2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 27-150 of human BMPR2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13873 (UniProt, ExPASy) |
| UniProt Secondary AC | Q13161, Q16569, Q4ZG08, Q53SA5, Q585T8 |
| UniProt Entry Name | BMPR2_HUMAN |
| Gene Symbol | BMPR2 |
| GeneID | 659 |
| NCBI Accession | NP_001195.2 |
| KEGG | hsa:659 |
| String | 9606.ENSP00000363708 |
| Molecular Weight | Calculated MW: 115 kDa Observed MW: 100 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |