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Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) Antibody
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Catalogue No: abx000366
Price:
US$232.00
(Size: 20 µl)
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BRCA1 (pS988) Antibody is a Rabbit Polyclonal antibody against BRCA1 (pS988). This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Research Articles on Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988)
| Target | Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) |
| Clonality | Polyclonal |
| Target Modification | Ser988 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around S988 of human BRCA1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P38398 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PFZ0, O15129, Q1RMC1, Q3LRJ0, Q3LRJ6, Q6IN79, Q7KYU9 |
| UniProt Entry Name | BRCA1_HUMAN |
| Gene Symbol | BRCA1 |
| GeneID | 672 |
| NCBI Accession | NP_009225.1 |
| KEGG | hsa:672 |
| String | 9606.ENSP00000418960 |
| Molecular Weight | Calculated MW: 208 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |