Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody is a Mouse Monoclonal antibody against Lys-63-Specific Deubiquitinase BRCC36 (BRCC3). This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Target	Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Form	Liquid
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P46736 (UniProt, ExPASy)
UniProt Secondary AC	A6QRF8, A6QRF9, A8MUX5, A8MWH0, A9Z1Y0, A9Z1Y5, B1B062, B4DQN7, Q16107, Q53YX5, Q9BTZ6
UniProt Entry Name	BRCC3_HUMAN
Gene Symbol	BRCC3
GeneID	79184
OMIM	300617
NCBI Accession	NP_001018065.1 NM_001018055.2 NP_001229569.1 NM_001242640.1 NP_077308.1 NM_024332.3
HGNC	24185
KEGG	hsa:79184
Ensembl	ENSG00000185515
String	9606.ENSP00000358474
Buffer	0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability	Please enquire.
Note	This product is for research use only.

Research Articles on Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)

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