+44 (0) 1223 755950
+1 832 327 7413
Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody
REQUEST MORE INFO
Catalogue No: abx230945
Price:
US$406.00
(Size: 100 µg)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody is a Rabbit Polyclonal against Lys-63-Specific Deubiquitinase BRCC36 (BRCC3). This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Research Articles on Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)
| Target | Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat, Monkey |
| Tested Applications | ELISA, WB, IHC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | BRCA1/BRCA2-containing complex, subunit 3 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P46736 (UniProt, ExPASy) |
| UniProt Secondary AC | A6QRF8, A6QRF9, A8MUX5, A8MWH0, A9Z1Y0, A9Z1Y5, B1B062, B4DQN7, Q16107, Q53YX5, Q9BTZ6 |
| UniProt Entry Name | BRCC3_HUMAN |
| Gene Symbol | BRCC3 |
| GeneID | 79184 |
| OMIM | 300617 |
| NCBI Accession | NP_001018065.1 NM_001018055.2 NP_001229569.1 NM_001242640.1 NP_077308.1 NM_024332.3 |
| HGNC | 24185 |
| KEGG | hsa:79184 |
| Ensembl | ENSG00000185515 |
| String | 9606.ENSP00000358474 |
| Molecular Weight | Observed MW: 65-70 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |