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Myc Proto-Oncogene Protein (c-Myc) Antibody
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Catalogue No: abx139766
Price:
US$362.50
(Size: 0.1 mg)
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c-Myc Antibody is a Mouse Monoclonal against c-Myc.
Research Articles on Myc Proto-Oncogene Protein (c-Myc)
| Target | Myc Proto-Oncogene Protein (c-Myc) |
| Clonality | Monoclonal |
| Clone | O971 |
| Reactivity | General (All species) |
| Tested Applications | ELISA, WB, IHC, FCM, IP, IF/ICC |
| Host | Mouse |
| Recommended dilutions | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of Human c-Myc. |
| Isotype | IgG1 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Storage | Store at 2-8°C. Do not freeze. |
| UniProt Primary AC | P01106 (UniProt, ExPASy) |
| GeneID | 4609 |
| KEGG | hsa:4609 |
| String | 9606.ENSP00000479618 |
| Buffer | PBS solution with 15 mM sodium azide. |
| Specificity | The antibody may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |