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Twinkle Protein, Mitochondrial (C10orf2) Antibody
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Catalogue No: abx027021
Price:
US$290.00
(Size: 80 µl)
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This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Research Articles on Twinkle Protein, Mitochondrial (C10orf2)
| Target | Twinkle Protein, Mitochondrial (C10orf2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 656-684 amino acids from the C-terminal region of human C10orf2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q96RR1 (UniProt, ExPASy) |
| UniProt Secondary AC | B2CQL2, Q6MZX2, Q6PJP5, Q96RR0 |
| UniProt Entry Name | PEO1_HUMAN |
| Gene Symbol | TWNK |
| KEGG | hsa:56652 |
| String | 9606.ENSP00000309595 |
| Molecular Weight | Calculated MW: 77.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |