Complement C2 (C2) Antibody

Complement C2 (C2) is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Target	Complement C2 (C2)
Clonality	Polyclonal
Reactivity	Human, Hamster
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P06681 (UniProt, ExPASy)
UniProt Secondary AC	B4DPF3, B4DV20, E9PFN7, O19694, Q13904
UniProt Entry Name	CO2_HUMAN
Gene Symbol	C2
GeneID	717
OMIM	217000
HGNC	1248
KEGG	hsa:717
Ensembl	ENSG00000166278
String	9606.ENSP00000299367
Molecular Weight	Calculated MW: 83.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Complement C2 (C2)

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