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Complement C2 (C2) Antibody
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Catalogue No: abx025830
Price:
US$326.25
(Size: 80 µl)
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Complement C2 (C2) is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Research Articles on Complement C2 (C2)
| Target | Complement C2 (C2) |
| Clonality | Polyclonal |
| Reactivity | Human, Hamster |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P06681 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DPF3, B4DV20, E9PFN7, O19694, Q13904 |
| UniProt Entry Name | CO2_HUMAN |
| Gene Symbol | C2 |
| GeneID | 717 |
| OMIM | 217000 |
| HGNC | 1248 |
| KEGG | hsa:717 |
| Ensembl | ENSG00000166278 |
| String | 9606.ENSP00000299367 |
| Molecular Weight | Calculated MW: 83.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |