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C4b-Binding Protein Beta Chain (C4BPB) Antibody
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Catalogue No: abx028563
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Research Articles on C4b-Binding Protein Beta Chain (C4BPB)
| Target | C4b-Binding Protein Beta Chain (C4BPB) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P20851 (UniProt, ExPASy) |
| UniProt Secondary AC | A5JYP8, D3DT81, Q5VVR0, Q9BS25 |
| UniProt Entry Name | C4BPB_HUMAN |
| Gene Symbol | C4BPB |
| GeneID | 725 |
| OMIM | 120831 |
| NCBI Accession | NP_000707.1 NM_000716.3 |
| HGNC | 1328 |
| KEGG | hsa:725 |
| Ensembl | ENSG00000123843 |
| String | 9606.ENSP00000243611 |
| Molecular Weight | Calculated MW: 28.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |