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Calpain-6 (CAPN6) Antibody
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Catalogue No: abx026878
Price:
US$290.00
(Size: 80 µl)
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Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
Research Articles on Calpain-6 (CAPN6)
| Target | Calpain-6 (CAPN6) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 390-419 amino acids from the Central region of human CAPN6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y6Q1 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DUY7, Q9UEQ1, Q9UJA8 |
| UniProt Entry Name | CAN6_HUMAN |
| Gene Symbol | CAPN6 |
| String | 9606.ENSP00000317214 |
| Molecular Weight | Calculated MW: 74.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat CAPN6. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |