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Caspase Recruitment Domain Family Member 11 (CARD11) Antibody
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Catalogue No: abx005391
Price:
US$217.50
(Size: 20 µl)
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CARD11 Antibody is a Rabbit Polyclonal antibody against CARD11. The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
Research Articles on Caspase Recruitment Domain Family Member 11 (CARD11)
| Target | Caspase Recruitment Domain Family Member 11 (CARD11) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 985-1154 of human CARD11. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9BXL7 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D1Z7, Q2NKN7, Q548H3 |
| UniProt Entry Name | CAR11_HUMAN |
| Gene Symbol | CARD11 |
| GeneID | 84433 |
| NCBI Accession | NP_115791.3 |
| String | 9606.ENSP00000380150 |
| Molecular Weight | Calculated MW: 133 kDa Observed MW: 133 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |