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Caspase Recruitment Domain Family Member 8 (CARD8) Antibody
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Catalogue No: abx000674
Price:
US$203.00
(Size: 20 µl)
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CARD8 Antibody is a Rabbit Polyclonal antibody against CARD8. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq].
Research Articles on Caspase Recruitment Domain Family Member 8 (CARD8)
| Target | Caspase Recruitment Domain Family Member 8 (CARD8) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CARD8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y2G2 (UniProt, ExPASy) |
| UniProt Secondary AC | B5KVR6, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82 |
| UniProt Entry Name | CARD8_HUMAN |
| Gene Symbol | CARD8 |
| GeneID | 22900 |
| NCBI Accession | NP_003796.1 |
| String | 9606.ENSP00000375767 |
| Molecular Weight | Calculated MW: 61 kDa Observed MW: 60 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |