Caspase Recruitment Domain Family Member 8 (CARD8) Antibody

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Catalogue No: abx000674
Price: US$478.50
(Size: 100 µl)
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Western blot analysis of various lysates using CARD8 Antibody at 1/1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Caspase Recruitment Domain Family Member 8 (CARD8) Antibody

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Datasheet SDS
CARD8 Antibody is a Rabbit Polyclonal antibody against CARD8. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq].

Target Caspase Recruitment Domain Family Member 8 (CARD8)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CARD8.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9Y2G2 (UniProt, ExPASy)
UniProt Secondary AC B5KVR6, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
UniProt Entry Name CARD8_HUMAN
Gene Symbol CARD8
GeneID 22900
NCBI Accession NP_003796.1
String 9606.ENSP00000375767
Molecular Weight Calculated MW: 61 kDa
Observed MW: 60 kDa
Buffer PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Caspase Recruitment Domain Family Member 8 (CARD8)
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