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Caspase 1 (CASP1) Antibody
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Catalogue No: abx148921
Price:
US$406.00
(Size: 100 µg)
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Caspase 1 (CASP1) Antibody is a Rabbit Polyclonal antibody for the detection of Caspase 1. CASP1 (caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing.
Research Articles on Caspase 1 (CASP1)
| Target | Caspase 1 (CASP1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | caspase 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P29466 (UniProt, ExPASy) |
| UniProt Secondary AC | B5MDZ1, Q53EY6, Q6DMQ1, Q6GSS3, Q6PI75, Q9UCN3 |
| UniProt Entry Name | CASP1_HUMAN |
| Gene Symbol | CASP1 |
| GeneID | 834 |
| OMIM | 147678 |
| HGNC | 1499 |
| KEGG | hsa:834 |
| Ensembl | ENSG00000137752 |
| String | 9606.ENSP00000433138 |
| Molecular Weight | Observed MW: 45-47 kDa, 30 kDa, 35 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |