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Caspase 14 (CASP14) Antibody
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Catalogue No: abx148925
Price:
US$406.00
(Size: 100 µg)
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Caspase 14 (CASP14) Antibody is a Rabbit Polyclonal antibody for the detection of CASP14. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Research Articles on Caspase 14 (CASP14)
| Target | Caspase 14 (CASP14) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | CASP14 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P31944 (UniProt, ExPASy) |
| UniProt Secondary AC | O95823, Q3SYC9 |
| UniProt Entry Name | CASPE_HUMAN |
| Gene Symbol | CASP14 |
| GeneID | 23581 |
| OMIM | 605848 |
| HGNC | 1502 |
| KEGG | hsa:23581 |
| Ensembl | ENSG00000105141 |
| String | 9606.ENSP00000393417 |
| Molecular Weight | Observed MW: 30 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |