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Caspase 3 (CASP3) Antibody
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Catalogue No: abx239937
Price:
US$406.00
(Size: 100 µg)
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Caspase 3 (CASP3) Antibody is a Mouse Monoclonal antibody for the detection of CASP3. Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Research Articles on Caspase 3 (CASP3)
| Target | Caspase 3 (CASP3) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/300, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | caspase 3, apoptosis-related cysteine peptidase |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P42574 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5M2, D3DP53, Q96AN1, Q96KP2 |
| UniProt Entry Name | CASP3_HUMAN |
| Gene Symbol | CASP3 |
| GeneID | 836 |
| OMIM | 600636 |
| HGNC | 1504 |
| KEGG | hsa:836 |
| Ensembl | ENSG00000164305 |
| String | 9606.ENSP00000311032 |
| Molecular Weight | Observed MW: 32-35 kDa, 19 kDa, 17 kDa |
| Buffer | 0.01 M PBS, pH 7.4. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |