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Caspase 6 (pS257) Antibody
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Catalogue No: abx031836
Price:
US$326.25
(Size: 80 µl)
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Caspase 6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.
Research Articles on Caspase 6 (pS257)
| Target | Caspase 6 (pS257) |
| Clonality | Polyclonal |
| Target Modification | Ser257 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S257 of human Caspase 6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P55212 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9BQE7 |
| UniProt Entry Name | CASP6_HUMAN |
| KEGG | hsa:839 |
| String | 9606.ENSP00000265164 |
| Molecular Weight | Calculated MW: 33.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat and Cow CASP6. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |