Caspase 8 (CASP8) Antibody

Caspase 8 (CASP8) Antibody is a Rabbit Polyclonal antibody for the detection of Caspase 8.

Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3 (PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.

Target	Caspase 8 (CASP8)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	caspase 8, apoptosis-related cysteine peptidase
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q14790 (UniProt, ExPASy)
UniProt Entry Name	CASP8_HUMAN
Gene Symbol	CASP8
GeneID	841
OMIM	211980
HGNC	1509
KEGG	hsa:841
Ensembl	ENSG00000064012
String	9606.ENSP00000351273
Molecular Weight	Observed MW: 53-57 kDa, 32-45 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Caspase 8 (CASP8)

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