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Calcium Sensing Receptor (CASR) Antibody
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Catalogue No: abx001232
Price:
US$348.00
(Size: 60 µl)
Click on the image to see the image legend
CASR Antibody is a Rabbit Polyclonal antibody against CASR. CASR, also named as GPRC2A, PCAR1, belongs to the G-protein coupled receptor 3 family. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. The activity of CASR is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
Research Articles on Calcium Sensing Receptor (CASR)
| Target | Calcium Sensing Receptor (CASR) |
| Clonality | Polyclonal |
| Reactivity | Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human CASR |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q969H0 (UniProt, ExPASy) |
| UniProt Secondary AC | B7ZLP9, Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6 |
| UniProt Entry Name | FBXW7_HUMAN |
| Gene Symbol | FBXW7 |
| GeneID | 846 |
| NCBI Accession | NP_000379.3 |
| KEGG | hsa:55294 |
| String | 9606.ENSP00000281708 |
| Molecular Weight | Calculated MW: 120 kDa/121 kDa Observed MW: 155 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
