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Catenin Beta (CTNNB1) Antibody
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Catalogue No: abx239904
Price:
US$406.00
(Size: 100 µg)
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Catenin Beta (CTNNB1) Antibody is a Mouse Monoclonal antibody for the detection of beta-Catenin. The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Research Articles on Catenin Beta (CTNNB1)
| Target | Catenin Beta (CTNNB1) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Rat, Pig |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Host | Mouse |
| Recommended dilutions | WB: 1/2000 - 1/20000, IHC: 1/200 - 1/1000, IF/ICC: 1/20 - 1/500, IP: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | catenin(cadherin-associated protein), beta 1, 88kDa |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P35222 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K1L7, Q8NEW9, Q8NI94, Q9H391 |
| Gene Symbol | CTNNB1 |
| GeneID | 1499 |
| OMIM | 114500 |
| HGNC | 2514 |
| Ensembl | ENSG00000168036 |
| Molecular Weight | Observed MW: 90 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |