Protein CBFA2T2 (CBFA2T2) Antibody

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Catalogue No: abx005323
Price: US$478.50
(Size: 100 µl)

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Western blot analysis of various lysates using CBFA2T2 Antibody at 1/1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Protein CBFA2T2 (CBFA2T2) Antibody Protein CBFA2T2 (CBFA2T2) Antibody

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Datasheet SDS
CBFA2T2 Antibody is a Rabbit Polyclonal antibody against CBFA2T2. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Target Protein CBFA2T2 (CBFA2T2)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IF/ICC
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 325-604 of human CBFA2T2.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O43439 (UniProt, ExPASy)
UniProt Entry Name MTG8R_HUMAN
Gene Symbol CBFA2T2
GeneID 9139
NCBI Accession NP_005084.1
KEGG hsa:9139
String 9606.ENSP00000262653
Molecular Weight Calculated MW: 67 kDa
Observed MW: 72 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration 0.58 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Protein CBFA2T2 (CBFA2T2)
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