+44 (0) 1223 755950
+1 832 327 7413
E3 Ubiquitin-Protein Ligase CBL-C (CBLC) Antibody
REQUEST MORE INFO
Catalogue No: abx026905
Price:
US$326.25
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Research Articles on E3 Ubiquitin-Protein Ligase CBL-C (CBLC)
| Target | E3 Ubiquitin-Protein Ligase CBL-C (CBLC) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 424-453 amino acids from the C-terminal region of human CBLC. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9ULV8 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8N1E5, Q9Y5Z2, Q9Y5Z3 |
| UniProt Entry Name | CBLC_HUMAN |
| String | 9606.ENSP00000270279 |
| Molecular Weight | Calculated MW: 52.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |