C-C Motif Chemokine 2 / MCP1 (CCL2) Antibody

CCL2 Antibody is a Rabbit Polyclonal antibody against CCL2. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Target	C-C Motif Chemokine 2 / MCP1 (CCL2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 24-99 of human CCL2/MCP-1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P13500 (UniProt, ExPASy)
UniProt Secondary AC	B2R4V3, Q9UDF3
UniProt Entry Name	CCL2_HUMAN
Gene Symbol	CCL2
GeneID	6347
OMIM	158105
NCBI Accession	NP_002973.1 NM_002982.3
HGNC	10618
KEGG	hsa:6347
Ensembl	ENSG00000108691
String	9606.ENSP00000225831
Molecular Weight	Calculated MW: 11 kDa Observed MW: 13-15 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on C-C Motif Chemokine 2 / MCP1 (CCL2)

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