C-C Motif Chemokine 5 (CCL5) Antibody

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Catalogue No: abx004305
Price: US$217.50
(Size: 20 µl)

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Datasheet SDS
CCL5 Antibody is a Rabbit Polyclonal antibody against CCL5. This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.

Target C-C Motif Chemokine 5 (CCL5)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-91 of human CCL5/RANTES.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P13501 (UniProt, ExPASy)
UniProt Secondary AC O43646, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99
UniProt Entry Name CCL5_HUMAN
Gene Symbol CCL5
GeneID 6352
NCBI Accession NP_002976.2
KEGG hsa:6352
String 9606.ENSP00000474412
Molecular Weight Calculated MW: 10 kDa
Observed MW: 13 kDa
Buffer PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on C-C Motif Chemokine 5 (CCL5)


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