Cyclin D1 (CCND1) Antibody

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Target	Cyclin D1 (CCND1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 264-292 amino acids from the C-terminal region of human CCND1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P24385 (UniProt, ExPASy)
UniProt Secondary AC	Q6LEF0
UniProt Entry Name	CCND1_HUMAN
NCBI Accession	NP_444284.1
KEGG	hsa:595
String	9606.ENSP00000227507
Molecular Weight	Calculated MW: 33.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow CCND1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cyclin D1 (CCND1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue