CD177 Antigen (CD177) Antibody

CD177 Antibody is a Rabbit Polyclonal antibody against CD177. This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.

Target	CD177 Antigen (CD177)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 35-285 of human CD177.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8N6Q3 (UniProt, ExPASy)
UniProt Secondary AC	Q711Q2, Q8NCV9, Q96QH1, Q9HDA5
UniProt Entry Name	CD177_HUMAN
Gene Symbol	CD177
GeneID	57126
NCBI Accession	NP_065139.2
KEGG	hsa:57126
String	9606.ENSP00000479536
Molecular Weight	Calculated MW: 51 kDa Observed MW: 105/45 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on CD177 Antigen (CD177)

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