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Programmed Cell Death 1 Ligand 1 (CD274) Antibody
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Catalogue No: abx001385
Price:
US$203.00
(Size: 20 µl)
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Programmed Cell Death 1 Ligand 1 Antibody is a Rabbit Polyclonal antibody against PD-L1 (CD274). Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1) is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
Research Articles on Programmed Cell Death 1 Ligand 1 (CD274)
| Target | Programmed Cell Death 1 Ligand 1 (CD274) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 190-290 of human PD-L1/CD274. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9NZQ7 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RBA2, B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5 |
| UniProt Entry Name | PD1L1_HUMAN |
| Gene Symbol | CD274 |
| GeneID | 29126 |
| NCBI Accession | NP_054862.1 |
| String | 9606.ENSP00000370989 |
| Molecular Weight | Calculated MW: 33 kDa Observed MW: 40-50 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 3 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |