Myeloid Cell Surface Antigen CD33 (CD33) Antibody

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Target	Myeloid Cell Surface Antigen CD33 (CD33)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 337-364 amino acids from human CD33.
Isotype	IgM
Form	Liquid
Purification	Purified Mouse Monoclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P20138 (UniProt, ExPASy)
UniProt Secondary AC	B4E3P8, C9JEN7, F8WAL2, Q8TD24
UniProt Entry Name	CD33_HUMAN
KEGG	hsa:945
String	9606.ENSP00000262262
Molecular Weight	Calculated MW: 39.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Myeloid Cell Surface Antigen CD33 (CD33)

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