TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. This antibody is supplied as crude ascites.

Target	TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/100 - 1/1600. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human CD40.
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25942 (UniProt, ExPASy)
UniProt Secondary AC	E1P5S9, Q53GN5, Q5JY15, Q5U007, Q7M4Q8, Q86YK5, Q9BYU0
UniProt Entry Name	TNR5_HUMAN
KEGG	hsa:958
String	9606.ENSP00000361359
Molecular Weight	Calculated MW: 30.6 kDa
Buffer	Ascites containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Pig and Horse CD40.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40)

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