Membrane Cofactor Protein (CD46) Antibody | Abbexa Ltd

Membrane Cofactor Protein (CD46) Antibody

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Catalogue No: abx034950
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Target Membrane Cofactor Protein (CD46)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P15529 (UniProt, ExPASy)
UniProt Entry Name MCP_HUMAN
NCBI Accession NP_002380.3 NP_722548.1 NP_758860.1 NP_758861.1 NP_758862.1 NP_758863.1 NP_758869.1 NP_758871.1
KEGG hsa:4179
String 9606.ENSP00000313875
Molecular Weight Calculated MW: 43.7 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Membrane Cofactor Protein (CD46)


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