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Membrane Cofactor Protein (CD46) Antibody
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Catalogue No: abx034950
Price:
US$326.25
(Size: 80 µl)
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Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Research Articles on Membrane Cofactor Protein (CD46)
| Target | Membrane Cofactor Protein (CD46) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P15529 (UniProt, ExPASy) |
| UniProt Entry Name | MCP_HUMAN |
| NCBI Accession | NP_002380.3 NP_722548.1 NP_758860.1 NP_758861.1 NP_758862.1 NP_758863.1 NP_758869.1 NP_758871.1 |
| KEGG | hsa:4179 |
| String | 9606.ENSP00000313875 |
| Molecular Weight | Calculated MW: 43.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |