Membrane Cofactor Protein (CD46) Antibody

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Target	Membrane Cofactor Protein (CD46)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P15529 (UniProt, ExPASy)
UniProt Entry Name	MCP_HUMAN
NCBI Accession	NP_002380.3 NP_722548.1 NP_758860.1 NP_758861.1 NP_758862.1 NP_758863.1 NP_758869.1 NP_758871.1
KEGG	hsa:4179
String	9606.ENSP00000313875
Molecular Weight	Calculated MW: 43.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Membrane Cofactor Protein (CD46)

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