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Cadherin-1 / E-Cadherin (CDH1) Antibody
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Catalogue No: abx012163
Price:
US$420.50
(Size: 100 µl)
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This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq].
Research Articles on Cadherin-1 / E-Cadherin (CDH1)
| Target | Cadherin-1 / E-Cadherin (CDH1) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Monkey |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human CDH1 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P12830 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K1U7, Q13799, Q14216, Q15855, Q16194, Q4PJ14, Q9UII8 |
| UniProt Entry Name | CADH1_HUMAN |
| GeneID | 999 |
| KEGG | hsa:999 |
| String | 9606.ENSP00000261769 |
| Molecular Weight | 135 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |