Cadherin 4 (CDH4) Antibody

CDH4 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.

Target	Cadherin 4 (CDH4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 175-203 amino acids from the N-terminal region of human CDH4.
Isotype	IgG
Form	Liquid
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS, then purified by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P55283 (UniProt, ExPASy)
UniProt Secondary AC	B3KWB8, G3V1P8, Q2M208, Q5VZ44, Q9BZ05
UniProt Entry Name	CADH4_HUMAN
KEGG	hsa:1002
String	9606.ENSP00000484928
Molecular Weight	Calculated MW: 100 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat CDH4.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cadherin 4 (CDH4)

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