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Cyclin-Dependent Kinase 4 (CDK4) Antibody
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Catalogue No: abx000696
Price:
US$377.00
(Size: 60 µl)
Orders to United States ship from United States
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CDK4 Antibody is a Rabbit Polyclonal antibody against CDK4. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Research Articles on Cyclin-Dependent Kinase 4 (CDK4)
| Target | Cyclin-Dependent Kinase 4 (CDK4) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IP: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human CDK4 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P11802 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R9A0, B4DNF9, O00576, Q6FG61 |
| UniProt Entry Name | CDK4_HUMAN |
| Gene Symbol | CDK4 |
| GeneID | 1019 |
| NCBI Accession | NP_000066.1 |
| KEGG | hsa:1019 |
| String | 9606.ENSP00000257904 |
| Molecular Weight | Calculated MW: 20 kDa/33 kDa Observed MW: 30 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
