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Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) Antibody
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Catalogue No: abx000672
Price:
US$203.00
(Size: 20 µl)
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CDKN1B Antibody is a Rabbit Polyclonal antibody against CDKN1B. This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Research Articles on Cyclin Dependent Kinase Inhibitor 1B (CDKN1B)
| Target | Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B/p27KIP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P46527 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16307, Q5U0H2, Q9BUS6 |
| UniProt Entry Name | CDN1B_HUMAN |
| Gene Symbol | CDKN1B |
| GeneID | 1027 |
| NCBI Accession | NP_004055.1 |
| KEGG | hsa:1027 |
| String | 9606.ENSP00000228872 |
| Molecular Weight | Calculated MW: 22 kDa Observed MW: 27 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |