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CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody
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Catalogue No: abx034233
Price:
US$326.25
(Size: 80 µl)
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Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. It lacks enzymatic (caspase) activity.
Research Articles on CASP8 And FADD Like Apoptosis Regulator (CFLAR)
| Target | CASP8 And FADD Like Apoptosis Regulator (CFLAR) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 145-174 amino acids from the Central region of human CFLAR. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O15519 (UniProt, ExPASy) |
| UniProt Entry Name | CFLAR_HUMAN |
| Gene Symbol | CFLAR |
| KEGG | hsa:8837 |
| String | 9606.ENSP00000312455 |
| Molecular Weight | Calculated MW: 55.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |