+44 (0) 1223 755950
+1 832 327 7413
Choline O-Acetyltransferase (CHAT) Antibody
REQUEST MORE INFO
Catalogue No: abx001939
Price:
US$203.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
CHAT Antibody is a Rabbit Polyclonal antibody against CHAT. This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
Research Articles on Choline O-Acetyltransferase (CHAT)
| Target | Choline O-Acetyltransferase (CHAT) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CHAT. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P28329 (UniProt, ExPASy) |
| UniProt Secondary AC | A2BDF4, A2BDF5, Q16488, Q9BQ23, Q9BQ35, Q9BQE1 |
| UniProt Entry Name | CLAT_HUMAN |
| Gene Symbol | CHAT |
| GeneID | 1103 |
| NCBI Accession | NP_065574.4 |
| KEGG | hsa:1103 |
| String | 9606.ENSP00000337103 |
| Molecular Weight | Calculated MW: 83 kDa Observed MW: 71 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |