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Acetylcholine Receptor Subunit Gamma (CHRNG) Antibody
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Catalogue No: abx029286
Price:
US$326.25
(Size: 80 µl)
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The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
Research Articles on Acetylcholine Receptor Subunit Gamma (CHRNG)
| Target | Acetylcholine Receptor Subunit Gamma (CHRNG) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human CHRNG. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P07510 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KWM8, Q14DU4, Q53RG2 |
| UniProt Entry Name | ACHG_HUMAN |
| KEGG | hsa:1146 |
| String | 9606.ENSP00000374145 |
| Molecular Weight | Calculated MW: 57.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |