Cytokine Inducible SH2 Containing Protein (CISH) Antibody

CISH Antibody is a Rabbit Polyclonal antibody against CISH. The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Cytokine Inducible SH2 Containing Protein (CISH)
Clonality	Polyclonal
Reactivity	Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human CISH.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NSE2 (UniProt, ExPASy)
UniProt Secondary AC	B2R9N1, G5E9R1, Q9NS38, Q9Y5R1
UniProt Entry Name	CISH_HUMAN
Gene Symbol	CISH
GeneID	1154
NCBI Accession	NP_659508.1
String	9606.ENSP00000409346
Molecular Weight	Calculated MW: 29 kDa Observed MW: 37 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cytokine Inducible SH2 Containing Protein (CISH)

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