Cbp/P300-Interacting Transactivator 2 (CITED2) Antibody

Cbp/P300-Interacting Transactivator 2 (CITED2) Antibody is a Rabbit Polyclonal antibody for the detection of CITED2.

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP) ; stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.

Target	Cbp/P300-Interacting Transactivator 2 (CITED2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q99967 (UniProt, ExPASy)
UniProt Secondary AC	O95426, Q5VTF4
UniProt Entry Name	CITE2_HUMAN
Gene Symbol	CITED2
GeneID	10370
OMIM	602937
HGNC	1987
KEGG	hsa:10370
Ensembl	ENSG00000164442
String	9606.ENSP00000444198
Molecular Weight	Observed MW: 27 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Cbp/P300-Interacting Transactivator 2 (CITED2)

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