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Keratin, Type I Cytoskeletal 17 (KRT17) Antibody
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Catalogue No: abx015731
Price:
US$427.75
(Size: 100 µl)
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CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17.It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages.Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair.May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells".May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state.Modulates the function of TNF-alpha in the specific context of hair cycling.Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway.Involved in tissue repair.
Research Articles on Keratin, Type I Cytoskeletal 17 (KRT17)
| Target | Keratin, Type I Cytoskeletal 17 (KRT17) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of CK17 expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q04695 (UniProt, ExPASy) |
| UniProt Entry Name | K1C17_HUMAN |
| Gene Symbol | KRT17 |
| GeneID | 3872 |
| OMIM | 148069 |
| HGNC | 6427 |
| KEGG | hsa:3872 |
| Ensembl | ENSG00000128422 |
| String | 9606.ENSP00000308452 |
| Molecular Weight | 49 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |