Casein Kinase 2-Interacting Protein 1 (CKIP-1) Antibody

CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). This protein may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). It appears to target ATM to the plasma membrane and appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Target	Casein Kinase 2-Interacting Protein 1 (CKIP-1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human CKIP-1.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q53GL0 (UniProt, ExPASy)
UniProt Secondary AC	Q336K5, Q8IZ51, Q9NRV3, Q9UL48
UniProt Entry Name	PKHO1_HUMAN
KEGG	hsa:51177
String	9606.ENSP00000358120
Molecular Weight	Calculated MW: 46.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow PLEKHO1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Casein Kinase 2-Interacting Protein 1 (CKIP-1)

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