+44 (0) 1223 755950
+1 832 327 7413
Creatine Kinase, Mitochondrial 1A (CKMT1A) Antibody
REQUEST MORE INFO
Catalogue No: abx004020
Price:
US$203.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
CKMT1A Antibody is a Rabbit Polyclonal antibody against CKMT1A. Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
Research Articles on Creatine Kinase, Mitochondrial 1A (CKMT1A)
| Target | Creatine Kinase, Mitochondrial 1A (CKMT1A) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 258-417 of human CKMT1A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P12532 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DIT8, B7ZA09, Q0VAM3, Q32NF6, Q53FC4 |
| UniProt Entry Name | KCRU_HUMAN |
| Gene Symbol | CKMT1A |
| GeneID | 548596 |
| OMIM | 123290 |
| NCBI Accession | NP_001015001.1 |
| HGNC | 31736 |
| KEGG | hsa:548596 |
| Ensembl | ENSG00000237289 |
| String | 9606.ENSP00000406577 |
| Molecular Weight | Calculated MW: 47 kDa Observed MW: 47 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |