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Cardiotrophin Like Cytokine Factor 1 (CLCF1) Antibody
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Catalogue No: abx030553
Price:
US$290.00
(Size: 80 µl)
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This gene is a member of the glycoprotein (gp) 130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Research Articles on Cardiotrophin Like Cytokine Factor 1 (CLCF1)
| Target | Cardiotrophin Like Cytokine Factor 1 (CLCF1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human CLCF1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UBD9 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DNT4, Q6NZA4 |
| UniProt Entry Name | CLCF1_HUMAN |
| Gene Symbol | CLCF1 |
| String | 9606.ENSP00000309338 |
| Molecular Weight | Calculated MW: 25.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse CLCF1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |