Chloride Channel Protein 1 (CLCN1) Antibody

CLCN1 Antibody is a Rabbit Polyclonal antibody against CLCN1. The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants.

Target	Chloride Channel Protein 1 (CLCN1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 779-988 of human CLCN1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35523 (UniProt, ExPASy)
UniProt Secondary AC	A4D2H5, Q2M202
UniProt Entry Name	CLCN1_HUMAN
Gene Symbol	CLCN1
GeneID	1180
NCBI Accession	NP_000074.3
KEGG	hsa:1180
String	9606.ENSP00000339867
Molecular Weight	Calculated MW: 109 kDa Observed MW: 109 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Chloride Channel Protein 1 (CLCN1)

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