Cleaved-CASP3 Antibody

CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

Target	Cleaved-CASP3
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC, DB
Host	Rabbit
Recommended dilutions	IHC-P: 1/50 - 1/100, DB: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 149-175 amino acids from human Cleaved.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42574 (UniProt, ExPASy)
UniProt Secondary AC	A8K5M2, D3DP53, Q96AN1, Q96KP2
UniProt Entry Name	CASP3_HUMAN
KEGG	hsa:836
String	9606.ENSP00000311032
Molecular Weight	Calculated MW: 31.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Pig CASP3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cleaved-CASP3

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